慢性中耳炎与Sjogren综合征的关联:一个病例对照研究
Tzong-Hann Yang1,2,3,4,5, Alison H Chang6, Yen-Fu Cheng3,5,7,8,9
1Department of Otorhinolaryngology, Taipei City Hospital, Taipei 110, Taiwan.
患有Sjögren的患者
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 肖格伦综合征是一种自身免疫性疾病,主要影响外分泌腺.
- 斯约格伦综合征与慢性中耳炎 (COM) 之间的关联在大型人口研究中尚未得到充分证实.
研究的目的:
- 调查Sjögren综合征与患慢性中耳炎的风险之间的关联.
- 利用代表性的台湾人口数据集来研究这种关系.
主要方法:
- 采用了基于人口的病例控制研究设计.
- 9473名患有慢性中耳炎的患者被确定为病例,并使用倾向性得分匹配与28419名对照进行匹配.
- 进行了多重后勤回归分析,调整了人口和临床因素.
主要成果:
- 与对照组相比,慢性中耳炎患者中观察到斯约格伦综合征的统计学上显著更高的患病率 (4.89%与2.93%相比,p < 0.001).
- 患有慢性中耳炎的患者显著增加患Sjögren综合征的可能性 (调整后OR=1.698).
- 这种关联在男性 (调整后OR=1.982) 和女性 (调整后OR=1.604) 患者子组中仍然显著.
结论:
- 患有Sjögren综合征的患者与慢性中耳炎的发生率显著增加有关.
- 研究结果表明,这种潜在的联系值得在Sjögren综合征患者的临床实践中加以考虑.
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