年龄对重症COVID-19患者死亡率的真正影响
Agamemnon Bakakos1, Evangelia Koukaki1, Sevasti Ampelioti1
11st University Department of Respiratory Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
仅仅年龄并不能预测重症患者的COVID-19死亡率. 综合标志物,如查尔森并发症指数 (CCI) 和控制败血症,对于在ICU中的生存至关重要.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 严重的COVID-19需要进入重症监护室 (ICU),对全球医疗保健系统造成重大压力.
- 患有COVID-19入院ICU的老年患者面临着独特的挑战和潜在的较差的结果.
研究的目的:
- 为了评估年龄对COVID-19重症患者死亡率的影响.
- 确定其他影响ICU生存的临床和实验室因素.
主要方法:
- 对300名入住希腊呼吸系统医院重症监护室的COVID-19患者进行了回顾性分析.
- 患者被分为两组:65岁以下和65岁以上.
- 住院后60天的存活率是主要终点;二级终点包括败血症,查尔森并发症指数 (CCI),APACHE II,d-二次体和CRP.
主要成果:
- 整体ICU存活率为75.7%. 在ICU中,总体存活率为75.7%. 65岁以下的患者的生存率为89.3%,65岁以上的患者的生存率为58% (p < 0.001).
- 多变量分析确定了败血症和增加的CCI作为60天死亡率的独立预测因素 (p < 0.001).
- 在多变量模型中,年龄组不是死亡率的统计学显著预测因素 (p = 0.320).
结论:
- 仅仅时间学年龄不足以预测严重的ICU COVID-19病例中的死亡率.
- 复合临床标记,如CCI,更好地反映生物年龄和预后.
- 预防败血症的有效感染控制对于改善患者的生存率至关重要,无论年龄如何.
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