使用数据驱动方法对精神分裂症谱系障碍进行深度临床表型化:向精确精神病学迈进
Tesfa Dejenie Habtewold1, Jiasi Hao1, Edith J Liemburg2
1Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Journal of personalized medicine
|June 28, 2023
概括
这项研究根据症状,认知和心理社会功能确定了不同类型的精神分裂症谱系障碍. 这些亚型表现出不同的过程,可以通过基线因素预测,帮助精确精神病学.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 精神分裂症谱系障碍 (SSD) 呈现出显著的异质性,由于缺乏客观诊断标准,使传统分类复杂化.
- SSD症状和相关因素的多维性质有助于诊断挑战.
- 深度临床表型是理解和分类SSD的关键.
研究的目的:
- 提供基因风险和精神病结果 (GROUP) 队列研究的概述.
- 根据症状,认知障碍和心理社会功能来确定精神分裂症谱系障碍中的潜在亚型.
- 探索这些已识别的亚型的纵向过程和预测因素,以推进精确精神病学.
主要方法:
- 在GROUP队列中利用了精神分裂谱系障碍的深度临床表型.
- 分析了积极和消极的症状,认知障碍和心理社会功能 (社会包容,病前调整).
- 采用潜变量建模来识别不同的亚型,并分析纵向数据以确定路径和预测因素.
主要成果:
- 确定了积极/消极症状的3-4个潜在亚型,认知障碍的4-6个亚型,以及心理社会功能的5个亚型.
- 发现确定的亚型表现出混合的形状和不同的纵向过程 (稳定,恶化,复发,改善).
- 发现基线阳性/阴性症状,病前调整,精神病类经历,生活质量和PRSSCZ显著预测了这些亚型.
结论:
- 已识别的亚型提供了超越传统分类的精神分裂症谱系障碍的更细致的理解.
- 这些发现对准确识别高风险群体和预测疾病预后具有临床意义.
- 这项研究通过提高诊断准确度和优化SSD的治疗选择来支持精密精神病学的进步.
相关概念视频
Biological Causes of Schizophrenia
104
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
104
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
763
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
763
Schizophrenia
150
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
150
Psychological and Sociocultural Causes of Schizophrenia
146
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
146
Human Genetics
625
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
625


