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Updated: Jul 25, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

隔离检查视觉唤起潜力的诊断能力,用于早期至中度的初级开角玻璃眼

Xia Wang¹, Yuan Fang¹, Ruoshi Li¹

¹Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China.

Life (Basel, Switzerland)

|June 28, 2023

概括

隔离检查视觉唤起潜力 (icVEP) 显示了初级开角青光眼 (POAG) 的诊断能力,与视野 (VF) 和图案视觉唤起潜力 (PVEP) 测试相当. IcVEP为那些在VF检查中扎的POAG患者提供了一个有价值的补充工具.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

主要开角青光眼 (POAG) 是全球不可逆转失明的主要原因.
早期诊断和监测POAG对于有效的管理和视力保护至关重要.
目前的诊断方法,如视野测试 (VF) 和模式视觉唤起潜力 (PVEP) 有局限性,特别是在某些患者群体.

研究的目的:

评估隔离检查视觉唤起潜力 (icVEP) 在识别POAG.在诊断性能.
将icVEP的诊断能力与已知的方法进行比较,包括VF和PVEP.
通过决策曲线分析,评估icVEP与VF和PVEP相关的临床实用性和益处.

主要方法:

一项涉及68名参与者的横截面研究 (33名POAG患者,35名对照) 进行了全面的眼科检查.
测试包括孤立检查视觉唤起潜力 (icVEP),模式视觉唤起潜力 (PVEP) 和视觉场 (VF) 测试.
计算了诊断性能指标,例如接收器操作特征曲线 (AUC) 下的面积,集成歧视指数 (IDI) 和净重新分类指数 (NRI). 使用决策曲线分析 (DCA) 来比较临床益处.

主要成果:

在icVEP信号与噪声比率 (SNR),VF平均偏差 (MD) 和模式标准偏差 (PSD) 以及PVEP P100延迟和振幅 (对于0.25°检查) 中观察到POAG患者和对照组之间的显著差异.
在icVEP,VF和PVEP的整体诊断能力 (AUC,IDI,NRI) 中没有发现显著差异.
决策曲线分析表明,icVEP (SNR) 的临床益处与VF (MD,PSD) 相当,并且优于PVEP (P100延迟,振幅).

结论:

隔离检查视觉唤起潜力 (icVEP) 显示了早期至中度初级开角青光眼 (POAG) 的诊断能力,与视野 (VF) 和模式视觉唤起潜力 (PVEP) 测试相当.
IcVEP显示出作为一种补充心理物理检查方法的潜力,特别是对于那些发现VF检查具有挑战性的POAG患者.
这些发现表明icVEP可以成为POAG诊断武器库的宝贵补充,提高诊断准确性和患者管理.

关键词:

诊断诊断诊断诊断诊断诊断玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼隔离检查 - 检查开放的角度开放的角度视觉唤起的潜在潜力

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