甲状腺结节与肥胖症
Elpida Demetriou1, Maria Fokou1, Savvas Frangos2
1Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus.
Life (Basel, Switzerland)
|June 28, 2023
概括
肥胖通过炎症和荷尔蒙变化促进甲状腺结节. 莱普和胰岛素等关键激素,以及代谢综合征,驱动甲状腺细胞的生长和癌症的发展.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理生理学 病理生理学
背景情况:
- 肥胖与系统性炎症的增加有关,这是甲状腺结节发展的关键因素.
- 莱普丁,雌激素和胰岛素等激素以及代谢综合征成分在甲状腺病理生理学中起着重要作用.
研究的目的:
- 审查肥胖导致甲状腺结节形成和进展的机制.
- 讨论肥胖在甲状腺结节病理生理学的临床影响.
主要方法:
- 本综述综合了有关分子和细胞通路的现有研究.
- 它检查了特定激素,炎症标志物和代谢因素的作用.
主要成果:
- 莱普通过炎症途径 (TNF,IL-6) 和信号级联 (JAK/STAT,MAPK,PI3K/Akt) 促进甲状腺结节和癌症的生长.
- 与代谢综合征相关的异常雌激素水平,高胰岛素血症,高血糖症和脂质失调症刺激甲状腺增殖和血管生成.
- 胰岛素抵抗会影响甲状腺血管,而胰岛素和TSH会影响甲状腺基因表达和细胞增殖.
结论:
- 与肥胖相关的因素对甲状腺结节和癌症的发展和进展至关重要.
- 了解这些机制可能会导致新的临床策略来管理肥胖个体的甲状腺疾病.
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