烧伤中的血流感染:一个14年的队列分析
Yarden Nitsani1, Tal Michael2, Dor Halpern1
1Joyce & Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba 8410501, Israel.
Life (Basel, Switzerland)
|June 28, 2023
概括
烧伤患者的血流感染很常见,并影响结果. 格拉姆阴性感染显著增加死亡风险,突出了基于烧伤特征的向治疗的需要.
科学领域:
- 传染性疾病 传染性疾病
- 烧伤护理 烧伤护理
- 临床微生物学 临床微生物学
背景情况:
- 血流感染 (BSI) 是烧伤患者严重疾病和死亡的主要原因.
- 识别致病原体对于有效的治疗和管理至关重要.
- 这项研究调查了烧伤患者中BSI的微生物学及其对住院结果的影响.
研究的目的:
- 在住院烧伤患者中描述导致BSI的病原体谱.
- 确定特定病原体与临床结果之间的关联,包括重症监护室 (ICU) 的入院,手术干预和死亡率.
- 为了确定BSI及其相关并发症的危险因素.
主要方法:
- 一项回顾性队列研究分析了2007年至2020年期间治疗的2029名烧伤患者的数据.
- 阳性血培养的患者被分为格兰正,格兰阴性,混合细菌或真菌感染组.
- 使用统计分析,包括多变量分析,来评估烧伤特征,病原体和结果之间的关系.
主要成果:
- 11.7%的住院烧伤患者患有BSI,其中Candida和Pseudomonas是最常见的病原体.
- 在感染和非感染患者之间观察到ICU入院,手术需要和死亡率的显著差异 (p < 0.001).
- 格拉姆阴性细菌感染独立地与明显更高的死亡风险相关 (OR = 9.29,p < 0.001). 火焰和电烧是ICU入院和手术的独立风险因素.
结论:
- 特定的烧伤特征与特定的病原体有关,可能指导实证治疗策略.
- 早期识别和向治疗格拉姆阴性BSI对于降低烧伤患者的死亡率至关重要.
- 了解烧伤感染的微生物环境对于改善患者的治疗结果至关重要.
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