在固体器官移植接收者中评估mRNA疫苗免疫性
Paraskevi Tsoutsoura1, Efstathios Xagas1, Sotirios Roussos2
1Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, Medical School of Athens, National and Kapodistrian University, 11527 Athens, Greece.
Medicina (Kaunas, Lithuania)
|June 28, 2023
概括
固体器官移植接受者在初始COVID-19疫苗接种后表现出延迟的抗体反应. 强剂量显著增强了抗体和T细胞反应,证明了疫苗在这个脆弱群体中的安全性和有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 移植医学 移植医学 移植医学
背景情况:
- 固体器官移植 (SOT) 接受者面临严重的COVID-19风险.
- 在SOT患者中,mRNA疫苗显示免疫性降低.
- 对于接受SOT的患者来说,优先考虑初级剂量和强剂量至关重要.
研究的目的:
- 评估SOT接种者在初级和辅助mRNA疫苗接种后的幽默和细胞免疫反应.
- 在SOT接种者中评估mRNA疫苗的安全性和耐受性.
主要方法:
- 对144名SOT接种者进行了分析,接种了两剂BNT162b2或mRNA1273的疫苗,随后接种了mRNA1273的助推剂.
- 测量抗体标位和SARS-CoV-2特异性T细胞响应在接种后的定义间隔.
- 强剂后不良事件的监测.
主要成果:
- 抗体血清阳性从第二剂后1个月的33.6%增加到第二剂后3个月的41.8%.
- mRNA1273助推剂显著增加了血清阳性,达到69.4%,中位数为966AU/mL.
- 特异性T细胞反应从初级疫苗接种后的11.4%增加到强剂接种后的42%.
- 在增剂后报告了轻微的副作用,主要是注射部位疼痛 (73.4%).
结论:
- 在初级接种疫苗后三个月,观察到抗体标位的延迟,轻微增加.
- 在SOT接种者中,mRNA疫苗的增强剂量强烈增强了幽默和T细胞免疫力.
- mRNA疫苗在SOT接种者中是安全的,耐受性很好,第三剂后免疫反应显著增加.
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