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三-酸盐-纳米颗粒含有水泥的影响:体外和体外研究
Naho Ezawa1, Yoshihiko Akashi2, Kei Nakajima2
1Department of Endodontics, Tokyo Dental College, Tokyo 101-0061, Japan.
Materials (Basel, Switzerland)
|June 28, 2023
概括
生物牙是一种新型的三酸纳米颗粒水泥,增强了人类牙周带纤维细胞的骨质分化,并促进了与矿物三氧化物聚合物 (MTA) 相比,在老鼠中更快地愈合牙孔孔.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 恢复性牙科 恢复性牙科
背景情况:
- 矿物三氧化聚合物 (MTA) 在牙科应用方面存在局限性.
- 作为MTA的替代品,开发了一种三酸纳米颗粒水泥Biodentine.
- 了解Biodentine对骨质生成和组织愈合的影响至关重要.
研究的目的:
- 在实验室中评估Biodentine对人类牙周带纤维细胞 (HPLF) 的骨质分化的影响.
- 评估Biodentine在治疗老鼠牙中孔的疗效,与MTA相比.
- 调查Biodentine骨质生成潜力的潜在机制.
主要方法:
- 在体外:pH值,释放,细胞附着 (SEM),增殖 (coulter counter),基因表达 (qRT-PCR) 和矿化 (阿利扎林红S).
- 在体内:用Biodentine或MTA填充的鼠毛孔穿孔模型.
- 组织学分析 (HE,Runx2,TRAP染色) 在7,14和28天.
主要成果:
- 生物牙在HPLF中显示出显著的骨质生成潜力.
- 在Biodentine中纳米颗粒尺寸分布似乎对早期骨质性活性至关重要.
- 在体内,与MTA相比,Biodentine促进了与MTA相比,大鼠毛孔孔的良好的愈合反应.
结论:
- 与MTA相比,Biodentine表现出有希望的骨质生成特性和优越的愈合潜力.
- 需要进一步的研究,以充分阐明Biodentine在骨质分化的作用机制.
- 生物牙代表了牙再生应用的可行替代方案.
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