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用于牙科应用的聚烯利多-酸盐-碳酸盐-氧酸盐多孔复合材料

Anna A Forysenkova¹, Inna V Fadeeva¹, Dina V Deyneko^2,3

¹A.A. Baikov Institute of Metallurgy and Material Science RAS, Leninsky, 49, 119334 Moscow, Russia.

Materials (Basel, Switzerland)

|June 28, 2023

概括

一种由聚烯 (PVP),酸盐 (Alg) 和碳酸酸盐 (CHA) 制成的新型多孔复合材料对牙组织修复有希望. 这种生物相容的复合物支持牙纸干细胞的活力,是目前牙替代疗法的潜在替代品.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
再生医学是一种再生医学.

背景情况:

目前的牙置换疗法往往涉及人工材料.
生物相容复合材料为恢复牙组织提供了一种替代方法.
聚合物-生物陶复合材料正在探索用于增强的牙科应用.

研究的目的:

准备和描述一种基于聚烯 (PVP),酸盐 (Alg) 和碳酸酸 (CHA) 的新型多孔复合材料.
评估复合物的体外生物相容性和牙科应用的潜力,特别是用于支持牙髓干细胞 (DPSC).

主要方法:

使用PVP,Alg和CHA的复合制剂.
通过X射线衍射,红外光谱,电子磁共振 (EPR) 和扫描电子显微镜 (SEM) 来进行材料特征.
在体外生物相容性评估使用MTT测定与小鼠纤维细胞和粘附/存活性测试与人类牙髓干细胞 (DPSC).

主要成果:

复合矿物成分被确定为碳酸酸 (CHA) 与无形酸.
EPR证实了聚合物矩阵和CHA颗粒之间的结合.
该材料表现出微型和纳米孔隙性,CHA增加了200%的水友性,并显示出DPSC的高细胞活力 (95±5%).

结论:

合成的PVP-Alg-CHA多孔复合物是生物相容的,并支持牙髓干细胞的粘附和存活.
该材料的性能,包括多孔性和增强的水友性,使其成为牙组织再生和恢复的有希望的候选者.
这种复合材料代表了传统牙置换疗法的可行替代方案.

关键词:

酸是一种酸.碳酸碳酸氧化酸这是一个复合材料.氧帕提特是一种氧帕提特.聚维尼尔皮罗利多的使用.

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