探索扩展性和泛耐药性 (XDR和PDR) 全基因组测序中的协同组合 Acinetobacter baumannii
Munawr Al Quraini1, Zaaema Al Jabri1, Hiba Sami2
1Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Microorganisms
|June 28, 2023
概括
斯福米辛与美罗相结合显示出与广泛耐药 (XDR) 和抗药性 (PDR) Acinetobacter baumannii 的显著协同作用. 这种组合为这些难以治疗的细菌引起的具有挑战性的感染提供了有希望的治疗选择.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 由于治疗选择有限,广泛耐药 (XDR) 和抗药性 (PDR) Acinetobacter baumannii 构成了重大挑战.
- 全基因组测序 (WGS) 有助于理解耐药机制和指导治疗策略.
研究的目的:
- 为了评估在体外的协同作用的菌素 (FOS) 与美罗 (MEM),阿米卡辛 (AK),tigecycline (TGC) 和胆固醇 (CL) 对抗XDR和PDR A. baumannii分离物.
- 确定有效的抗生素组合来治疗由多药耐药A. baumannii引起的感染.
主要方法:
- 8个A. baumannii分离物 (7个XDR,1个PDR) 的全基因组测序.
- 在体外协同测试使用棋盘 (CB) 和杀时测试 (TKA) 与葡萄糖-6-酸盐.
- 确定FOS,MEM,AK,TGC和CL的最小抑制度 (MIC) 的方法.
主要成果:
- 在90%的CB隔离物中,胺-美罗 (FOS-MEM) 显示出协同作用,在6/8的病例中将MEM MIC降低到敏感水平.
- 在所有测试的隔离物中,素-美罗 (CL-MEM) 显示出了出色的协同作用.
- 尽管存在广泛的耐药性基因,包括氨基糖化物,β-乳酸盐和宏类的耐药性基因,但仍观察到协同作用.
结论:
- 斯福米辛 - 梅罗和胆 - 梅罗的组合显示出治疗XDR和PDRAcinetobacter baumannii感染的前景.
- 针对内在耐药菌株的FOS-MEM的协同活性突显了其潜在的临床实用性.
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