COVID-19结果和糖尿病:一个全面的多中心前性队列研究
Karolina Akinosoglou1, Georgios Schinas1, Evanthia Bletsa2
1Department of Internal Medicine, Faculty of Medicine, University of Patras, University Hospital of Patras, 265 04 Patras, Greece.
患有COVID-19住院的2型糖尿病 (T2D) 患者面临严重的结果. 用于T2D管理的DPP4抑制剂与增加死亡风险,ICU入院,ARDS和血栓的风险有关.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 2型糖尿病 (T2D) 与严重的COVID-19结局有关.
- 在COVID-19期间对T2D患者的最佳管理是令人担忧的.
- 了解治疗对COVID-19严重性的影响至关重要.
研究的目的:
- 调查COVID-19住院的T2D患者的临床特征和结果.
- 探索慢性T2D治疗和不良COVID-19结果之间的关联.
- 评估DPP4抑制剂对T2D患者严重COVID-19结局的影响.
主要方法:
- 多中心前性队列研究.
- 包括354名在希腊因COVID-19住院的T2D患者 (2021年2月至6月).
- 临床数据的分析,包括住院死亡率,ICU入院,ARDS和血栓栓塞事件,按T2D治疗分层.
主要成果:
- 18.6%的T2D患者在住院期间死亡; 16.4%需要接受ICU治疗.
- 使用DPP4抑制剂与增加住院死亡风险有关 (adj. 或是2.639).
- DPP4抑制剂与更高的ICU入院率相关 (adj. 或2.524),ARDS (adj. 调整) 的情况. OR 2.507),以及血栓塞栓事件 (adj. 其他国家 (OR 2.249).
结论:
- 在T2D患者中使用DPP4抑制剂可能会增加严重COVID-19结局的风险.
- 研究结果强调需要在COVID-19管理中考虑T2D治疗方案.
- 需要进一步的研究来阐明这些关联背后的机制.
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