唾液降低糖糖诱导的空性在一个实验性的生物空模型
Rodrigo A Giacaman1,2, Rodrigo Umaña1, María José Nuñez1
1Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca 3462227, Chile.
Microorganisms
|June 28, 2023
概括
唾液,即使是少量,也可以通过减少酸的产生和细菌的生长来帮助预防牙. 更高的唾液度提供了更好的保护,防止由糖引起的空洞.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙虫研究 牙虫研究
- 生物膜研究研究的研究.
背景情况:
- 唾液在抑制腐烂过程中的作用尚未完全理解.
- 突变性链球菌 (S. mutans) 是牙虫的关键病因因因子.
- 了解不同唾液度的保护作用对于脏病预防策略至关重要.
研究的目的:
- 为了评估不同唾液稀释对体外空模型的影响.
- 为了研究唾液对Streptococcus mutans生物膜和牙/牙去矿化的剂量依赖作用.
主要方法:
- 在质和牙基板上培养S. mutans生物膜.
- 生物膜暴露于不同度的唾液 (0-100%) 和10%的糖糖溶液.
- 分析了脱矿,生物质,活力细菌,多糖形成和耗费介质的酸性.
主要成果:
- 在唾液比例和酸性/脱矿性之间发现了度依赖的反向关系.
- 即使是低度的唾液也显著减少了牙和牙的去矿化.
- 唾液显著降低了S. mutans生物量,可活细胞数量和多糖化物生产,以剂量依赖的方式.
结论:
- 唾液表现出剂量依赖的虫保护作用,防止糖糖诱导的菌性.
- 观察到显著抑制了去矿化和细菌活动,即使唾液的存在最小.
- 高液度几乎可以取消S. mutans生物膜的化潜力.
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