罕见的格拉姆阴性杆菌和肺移植接受者:叙述性审查
Eric Farfour1, Antoine Roux2, Edouard Sage3
1Service de Biologie Clinique, Hôpital Foch, 92150 Suresnes, France.
肺移植接受者通常携带非发酵的格拉姆阴性杆菌. 本综述详细介绍了由较罕见的属引起的感染,不包括像Pseudomonas aeruginosa这样的常见罪祸首.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 移植免疫学 移植免疫学
背景情况:
- 肺移植接受者 (LTR) 容易受到非发酵的格拉姆阴性杆菌 (GNR) 的呼吸道殖民.
- 分子测序的进步扩大了已知的细菌物种的多样性.
- 常见的GNR病原体如Pseudomonas aeruginosa经常被研究,但较少的GNR在LTR文献中代表性不足.
研究的目的:
- 审查LTR中由非发酵GNR引起的细菌感染,不包括通常识别的物种.
- 突出肺移植受体中新出现的或不太常见的GNR病原体.
- 讨论与这些较罕见的GNR感染相关的临床挑战.
主要方法:
- 在LTR中细菌感染的系统性文献综述.
- 排除标准包括Pseudomonas aeruginosa,Stenotrophomonas maltophilia,Achromobacter spp.和Burkholderia spp. 这些病毒都被排除在外.
- 报告的非发酵GNR种类的识别和分析.
主要成果:
- 在17个LTR病例中发现了非发酵的GNR.
- 涉及的属包括阿塞托巴克特,波德特拉,克里索巴克特,伊丽莎白金加,英基利努斯和潘多雷亚.
- 这些发现代表了这个人群中较少遇到的GNR感染.
结论:
- 更罕见的非发酵GNR属对肺移植接受者构成风险.
- 检测,识别,抗菌素耐药性,病原体和交叉传播方面的挑战需要进一步调查.
- 在LTR护理中,对更广泛的GNR频谱进行临床警至关重要.
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