与微生物组相关的和感染控制的方法,以初级和二级预防Clostridioides difficile感染
Lynne V McFarland1, Ellie J C Goldstein2, Ravina Kullar3
1McFarland Consulting, Seattle, WA 98115, USA.
Microorganisms
|June 28, 2023
概括
困难菌感染 (CDI) 是一个越来越令人担忧的问题. 通过益生菌或便微生物治疗恢复肠道微生物群,有望预防CDI,但需要更多的研究.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 困难菌感染 (CDI) 是全球紧急的医疗保健威胁,最近有报道称病例正在增加.
- 虽然有治疗方法,但对CDI的有效预防策略有限.
- CDI是一种机会性感染,与保护性肠道微生物群的破坏有关.
研究的目的:
- 提供2018年至2023年期间发布的CDI预防策略的最新审查.
- 为临床医生和医疗保健系统提供最佳CDI预防方法的指导.
- 专注于用于CDI预防的微生物组恢复策略.
主要方法:
- 使用PubMed,谷歌学者和clinicaltrials.gov.gov进行了文献搜索.
- 搜索的重点是针对CDI的初级或二级预防的2-3期临床试验.
- 关键词包括"微生物组"和"益生菌"与CDI预防有关.
主要成果:
- 旨在恢复肠道微生物组的策略被认为是预防CDI的合理策略.
- 益生菌,便微生物疗法和活生物疗法产品显示出潜力.
- 需要进一步的大型随机对照试验来验证这些发现并记录微生物组的变化.
结论:
- 恢复肠道微生物组是预防Clostridioides difficile感染的一个有希望的途径.
- 具体的干预措施,如益生菌和便微生物治疗,需要进一步调查.
- 更强大的临床试验是必要的,以确认有效性和了解微生物组的动态在预防CDI.
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