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波旁病毒在纽约州的多样化

Rachel E Lange^1,2, Alan P Dupuis², Alexander T Ciota^1,2

¹Department of Biomedical Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA.

|June 28, 2023

概括

波旁病毒 (BRBV) 正在美国东北部蔓延,新的菌株显示出遗传和表型多样性. 这种多元化可能有助于BRBVV.

科学领域:

病毒学病毒学
流行病学流行病学
遗传学是一个遗传学.

背景情况:

波本病毒 (BRBV) 是Ortomyxoviridae家族的病毒,是通过传播的,并于2014年在美国首次被发现.
孤独星 (Amblyomma americanum) 是BRBV的主要载体.
最初仅限于美国中西部,自2020年以来,BRBV最近在东北各州出现.

研究的目的:

在纽约州 (NYS) 调查波旁病毒菌株的遗传和表型特征.
了解BRBV在美国东北部的多样化和潜在传播.

主要方法:

来自纽约州的BRBV菌株的全基因组测序.
评估哺乳动物细胞培养中的复制动力学.
在Amblyomma americanum nymphs.病毒适应性的评估.

主要成果:

在NYS中发现了两种不同的BRBV菌群.
一个NYS菌株 (BRBV NY21-2143) 与中西部菌株相似,但具有独特的糖蛋白替代.
其他NYS菌株 (BRBV NY21-1814,BRBV NY21-2666) 构成一个新类.
BRBV NY21-2143在动物细胞中的复制减少,但在虫中增强了适应性.

结论:

在纽约州出现的BRBV菌株表现出显著的遗传和表型多样化.
这种多样化可能有助于波旁病毒在美国东北部的地理扩散.
需要进一步的研究来评估这些不断变化的BRBV菌株对公共卫生的影响.

关键词:

安布利莫玛是美国人的.威士忌病毒的病毒纽约州纽约州

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