由耐卡巴尼姆肠道细菌引起的医院感染:一项观察性研究
Hamzah J Aldali1,2, Azra Khan2, Abdullah A Alshehri3
1Cellular and Molecular Medicine, College of Biomedical Science, University of Bristol, Bristol BS8 1DT, UK.
由大肠杆菌和K. pneumoniae引起的在医院获得的抗卡巴因的感染正在增加. 英国的爆发风险很小,但有效的患者管理和感染控制对于预防传播至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 在医院获得的感染 (HAI) 对全球死亡率和发病率构成重大风险.
- 产生卡巴酶的肠杆菌 (CRE),特别是大肠杆菌和肺炎杆菌,在世界各地的医疗机构中越来越令人担忧.
研究的目的:
- 分析2009年至2021年在英国医院获得的耐卡巴尼姆的大肠杆菌和肺炎的流行情况.
- 评估有效的患者管理策略,以控制CRE的传播.
主要方法:
- 通过使用PubMed,Web of Science,Scopus,Science Direct和Cochrane Library等数据库进行了系统的文献审查.
- 从1094篇相关文章的初步选中选择了14篇符合条件的文章,以收集2009年至2021年期间英国医院中CRE的数据.
主要成果:
- 在超过63家英国医院中,发现了超过1083例耐卡巴胺的大肠杆菌和2053例耐卡巴胺的肺炎病例.
- 在K. pneumoniae.中,KPC是主要的碳烯酶. 与其他卡巴尼马相比,K. pneumoniae对科里斯等治疗方法的耐药性更强.
结论:
- 目前,英国面临着CRE爆发的最小风险.
- 实施强有力的治疗方案和感染控制措施至关重要,以防止CRE的区域和全球传播.
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