AgNPs和生物炭的协同作用:对抗肺癌和致病细菌的潜在组合
Maha N Abu Hajleh1, Muhamad Al-Limoun2, Amjad Al-Tarawneh3
1Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
Molecules (Basel, Switzerland)
|June 28, 2023
概括
生物合成的银纳米粒子 (AgNPs) 与生物炭相结合,显示出增强的抗菌活性和减少炎症标志物. 这种协同方法为对抗致病性细菌和肺癌细胞提供了一个有希望的战略.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 生物纳米材料合成对于纳米技术应用至关重要.
- 埃梅里塞拉牙被用于银纳米粒子 (AgNP) 生物合成.
- 合成了来自生物质的多孔材料生物炭.
研究的目的:
- 评估生物合成的AgNP和生物炭的协同作用.
- 评估它们对促炎性细胞因子和抗丧性基因表达的影响.
- 为了确定它们的联合抗菌活性.
主要方法:
- 使用Emericella dentata生物合成AgNP,并通过XRD,SEM和FTIR进行表征.
- 生物炭是通过生物质热解合成的.
- 分析了抗菌活性,基因表达和细胞因子水平的AgNPs,生物炭及其组合.
主要成果:
- SEM证实AgNP大小主要在10-80nm之间 (超过70%<40nm).
- 在AgNPs上,FTIR表明稳定/减少功能组.
- 与单个成分相比,AgNP-生物炭组合显著增强了抗菌功效,并减少了促炎性细胞因子和抗亡基因表达.
结论:
- 仅生物炭本身就没有表现出抗菌作用.
- 低剂量AgNPs和生物炭的组合显示出显著的协同抗菌和抗炎作用.
- 这种组合材料具有针对病原细菌和肺癌上皮细胞的强大策略.
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