与胺相关的死亡和改变的大脑化学物质:使用比较毒基因组数据库进行初步调查
Murad Tumayhi1, David Banji1, Ibrahim Khardali2
1Department of Pharmacology & Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
Molecules (Basel, Switzerland)
|June 28, 2023
概括
滥用安非他胺会改变大脑的化学成分,降低必需的欧米茄-3脂肪酸,如阿拉基酸 (AA) 和多可沙赫酸 (DHA). 这可能会导致神经毒性和精神健康障碍.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 滥用安非他胺会带来显著的毒性风险,并与有机特征的改变有关,包括欧米茄脂肪酸.
- 低欧米茄脂肪酸水平与各种精神健康障碍有关.
研究的目的:
- 为了调查与安非他命有关的死亡事件中大脑的化学特征.
- 通过使用比较毒基因组数据库 (CTD) 探索胺滥用,欧米茄脂肪酸水平和神经毒性之间的潜在联系.
主要方法:
- 氨基胺病例根据脑样本度被分为低,中,高.
- 使用CTD数据库来识别化学疾病的关联.
- 在所有组中确定了共享的化学化合物,包括阿拉基酸 (AA) 和多可沙赫萨酸 (DHA).
主要成果:
- 在所有安非他胺暴露组中发现的常见化合物包括1-octadecene,1-tridecene,2,4-di-tert-butylphenol,阿拉基酸 (AA),docosahexaenoic acid (DHA),eicosane和oleylamide.
- CTD分析预测了DHA,AA和自闭症,可卡因相关疾病,阿尔茨海默病和认知功能障碍等疾病之间的关联.
- 暴露于安非他胺可能导致omega-3脂肪酸的减少和人类大脑中氧化产品的增加.
结论:
- 氨基胺诱导的神经毒性可能是由于omega-3脂肪酸 (AA和DHA) 减少和氧化应激增加造成的.
- 预防omega-3脂肪酸缺乏的补充疗法可能有助于控制安非他胺毒性.
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