一个SARS-CoV-2:伴侣动物传播和变种分类
Rachana Pandit1, Qiana L Matthews1,2
1Microbiology Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA.
Pathogens (Basel, Switzerland)
|June 28, 2023
概括
像SARS-CoV-2这样的新型病毒对全球健康构成风险. 本综述考察了SARS-CoV-2变种,动物储库和传播,强调正在进行的根除研究.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 新出现的传染病,特别是冠状病毒 (SARS-CoV,MERS-CoV,SARS-CoV-2),对全球健康构成重大威胁.
- 广泛的SARS-CoV-2流行病导致了许多变种的出现,这些变种具有改变的传染性,感染性和免疫逃避.
- 这些病毒感染了各种各样的宿主,包括人类,伴侣动物,农场动物,动物园动物和野生动物.
研究的目的:
- 审查最近的SARS-CoV-2疫情,重点关注其变种.
- 讨论潜在的动物水库和伴侣和农场动物的自然感染.
- 强调持续研究和监测病毒流行病学,动物传播,变种和血清流行的重要性.
主要方法:
- 这是一篇综述文章,综合了有关SARS-CoV-2的现有研究.
- 它专注于分析与病毒特征,宿主相互作用和流行病学趋势相关的数据.
- 关注的重点领域包括SARS-CoV-2变种,动物水库和自然感染.
主要成果:
- 该评论讨论了SARS-CoV-2变种的特征及其对疾病传播的影响.
- 它探讨了各种动物物种作为SARS-CoV-2的潜在储库和宿主的作用.
- 在不同动物种群中出现SARS-CoV-2是当前大流行病的一个关键方面.
结论:
- 虽然疫苗和抗病毒药物有助于管理COVID-19,但完全根除需要持续的研究和监测.
- 了解病毒流行病学,动物传播动态和不同宿主之间的变异演变是至关重要的.
- 持续监测人类和动物种群中的血清流行和病毒特征对于未来的流行病准备是必不可少的.
相关概念视频
Single Nucleotide Polymorphisms-SNPs
15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K
Viral Recombination
23.6K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.6K
Viruses with RNA Genomes
58
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
58
Viral Mutations
32.5K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.5K
Subviral Agents
48
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
48
Incomplete Dominance
22.9K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.9K


