HSV使CRISPR-Cas9

Min Ying1,2,3,4, Huadong Wang2,3,4, Tongtan Liu2,3

  • 1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.

PubMed
概括

一种名为CLEAR的新CRISPR-Cas9策略通过向关键病毒基因,有效地抑制了简单疹病毒1型 (HSV-1) 复制. 组合基因编辑,称为"尾酒",在阻止病毒增殖方面表现出卓越的疗效,为治疗耐药HSV-1感染提供了希望.