根除Helicobacter pylori与耳肠轴微生物群的组成模式有显著的关联
Sally Ali Tawfik1, Marwa Azab1, Mohammed Ramadan2
1Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
根除Helicobacter pylori (H. pylori) 显著改变了口腔肠道微生物群,减少了总体的细菌多样性. 在治疗后,特定的口腔细菌,如Fusobacterium和Veillonella增加,影响肠道健康.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 传染病 传染病 传染病
背景情况:
- 杆菌 (H. pylori) 感染是胃疾病的主要危险因素,包括,胃炎和腺癌.
- 了解H. pylori对口腔肠道微生物群的影响对于管理相关的健康风险至关重要.
研究的目的:
- 为了研究H. pylori根除疗法之前和之后的口腔肠道微生物组的组成变化.
- 确定与H. pylori感染和其根除相关的特定细菌属和类型.
主要方法:
- 收集了15名H. pylori阳性个体的便和唾液样本,在根除治疗前和2个月后进行.
- 使用MiSeq对16SrRNA基因的V3-V4区域进行了测序,以分析细菌社区组成.
主要成果:
- 口腔微生物群的多样性高于肠道微生物群.
- 根除H. pylori导致口腔肠道细菌多样性的显著减少.
- 感染期间,特定的口腔属如Streptococcus,Haemophilus和Staphylococcus占主导地位,而Fusobacterium和Veillonella在根除后增加.
- 肠道微生物群在感染期间显示了Clostridium和Escherichia_Shigella的占主导地位,而Bifidobacterium和Faecalibacterium在根除后增加.
- 根除H. pylori与O3和O4类型有关,其中O4的特征是丰富的Veillonella和Fusobacteria.
结论:
- 杆菌根除疗法显著影响口腔肠道微生物群,特别是口腔微生物群.
- 根除后特定细菌属的变化需要进一步调查潜在的健康影响.
- 了解这些微生物组转变对于开发有针对性的干预措施和管理与H. pylori相关的疾病至关重要.
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