治疗性禁食在减少癌症患者化疗副作用:系统性审查和元分析
Yvelise Ferro1, Samantha Maurotti2, Maria Grazia Tarsitano1
1Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy.
Nutrients
|June 28, 2023
概括
这次审查没有发现任何证据表明禁食方案可以预防化疗副作用. 治疗性禁食似乎并不优于非禁食,以减少癌症治疗的毒性.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 化疗往往会引起显著的副作用,影响患者的生活质量和治疗坚持.
- 治疗性禁食被探索为减轻化疗引起的毒性的一种潜在策略.
研究的目的:
- 系统地审查和分析现有证据,以了解类似禁食的饮食方案在预防化疗相关副作用方面的有效性.
- 评估正在接受化疗的癌症患者的禁食与非禁食方法的比较有效性.
主要方法:
- 在PubMed,Scopus和Embase上进行了全面的文献搜索,截至2022年11月24日.
- 包括所有临床试验和病例系列报告化疗毒性与禁食方案.
- 对九项已识别的研究 (五项随机试验) 的汇总数据进行了元分析和敏感性分析.
主要成果:
- 中等到高质量的证据表明,各种禁食方案在减少不良事件方面没有比传统饮食提供显著的好处.
- 综合估计显示,禁食和非禁食组之间的总体副作用 (RR = 1.10;95% CI: 0.77-1.59) 或中性质减退 (RR = 1.33;95% CI: 0.90-1.97) 没有统计学上显著的差异.
- 敏感性分析证实了这些发现的可靠性.
结论:
- 目前的证据不支持使用治疗性禁食作为预防化疗毒性的优越方法,与非禁食相比.
- 需要进一步的研究来开发能够最大限度地减少或消除毒性的癌症治疗方法.
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