在新加坡前列腺癌研究中,维生素A和E形式与前列腺癌风险之间的关联
Wei Qi Loh1, Xin Yin1, Rie Kishida1
1Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
Nutrients
|June 28, 2023
概括
某些维生素A和E形式的较高水平与前列腺癌风险增加有关. 吸烟和饮酒显著改变了这些关联,影响了癌症病因.
科学领域:
- 营养生物化学 营养生物化学
- 癌症流行病学癌症流行病学
- 微量营养素研究的研究.
背景情况:
- 前列腺癌是全球男性癌症死亡的主要原因.
- 饮食因素,包括维生素A和E,正在研究它们在预防癌症中的作用.
- 了解这些维生素的特定形式及其对前列腺癌风险的影响至关重要.
研究的目的:
- 研究各种维生素A和E形式的血清度与前列腺癌风险之间的关联.
- 在这些关联中识别潜在的效果修饰因素,如吸烟和饮酒.
主要方法:
- 一项基于医院的病例对照研究 (新加坡前列腺癌研究) 涉及156名前列腺癌患者和118名对照.
- 用高性能液态染色学测量了15种维生素A和E形式的血清度.
- 用物流回归和加权定量总回归来分析数据,根据吸烟和酒精状态进行分层.
主要成果:
- 高血清水平的视网醇,黄蛋白,α-胡卜素,β-胡卜素,乌比昆,α-托科菲罗尔,δ-托科特里诺尔,γ-托科特里诺尔和α-托科特里诺尔显示出与整体前列腺癌风险的积极关联.
- 对于特定的维生素形式,在经常吸烟者和经常饮酒者中,相关性更为明显.
- 乙醇和α-托克醇分别是"维生素A"和"维生素E"组指数的关键贡献者.
结论:
- 特定的血清形式的维生素A和E与前列腺癌风险有关.
- 吸烟和饮酒显著改变了这些关联,影响了前列腺癌的发展.
- 这些发现有助于理解前列腺癌复杂的病因.
更多相关视频
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.1K
11:56In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
Published on: May 15, 2014
9.1K
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K
Vitamins
823
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
823
Cancer Vaccines
433
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
433
What is an Experiment?
11.8K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
11.8K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
