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在用放射性治疗的分化甲状腺癌患者中的Faecalibacterium prausnitzii

Ana Fernandes¹, Ana Oliveira¹, Ana Luísa Carvalho¹

¹Department of Nuclear Medicine, Centro Hospitalar Universitário de São João, E.P.E., 4200-319 Porto, Portugal.

|June 28, 2023

概括

差异化甲状腺癌患者的肠道细菌Faecalibacterium prausnitzii的水平显著降低. 放射性治疗没有伤害这种有益的细菌,甚至可能增加其丰富度.

科学领域:

微生物组研究的研究.
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

菌 (Faecalibacterium prausnitzii) 是一种关键的肠道细菌,产生丁酸盐,影响甲状腺健康和癌症治疗.
短链脂肪酸影响甲状腺生理学和对癌症治疗的反应.

研究的目的:

为了比较Faecalibacterium prausnitzii在差异化甲状腺癌患者中的丰富度与对照.
在放射性治疗 (RAIT) 后评估Faecalibacterium prausnitzii水平的变化.

主要方法:

快枪元基因组学被用来确定Faecalibacterium prausnitzii的丰富性.
从37名差异化甲状腺癌患者 (RAIT前后) 和10名健康志愿者收集了便样本.

主要成果:

与对照组相比,甲状腺癌患者的Faecalibacterium prausnitzii相对丰度显著降低.
大多数患者在RAIT后表现出Faecalibacterium prausnitzii丰度的增加,表明混合反应.

结论:

甲状腺癌与肠道失调有关,特别是Faecalibacterium prausnitzii的减少.
放射性治疗没有对Faecalibacterium prausnitzii产生负面影响;它可能有助于减轻辐射引起的问题.

关键词:

便细菌 (Faecalibacterium prausnitzii) 是一种可以引起便的细菌.我们的肠道微生物群.大基因组测序的测序.放射性治疗是一种放射性治疗.甲状腺癌是一种癌症.

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