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肌肉特征,sarcopenia,和sarcopenic肥胖症:一个维生素D 门德尔随机化研究

Joshua P Sutherland¹, Ang Zhou^1,2,3, Elina Hyppönen^1,2

¹Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.

|June 28, 2023

概括

较高的维生素D水平与更好的骨肌肉强度和质量有因果关系. 虽然没有降低形肥胖风险,但维生素D的充足量可能会对抗与年龄相关的肌肉衰弱.

科学领域:

遗传学是一个遗传学.
营养科学营养科学
老年学是一门学科.

背景情况:

观察性研究将维生素D缺乏与肌肉疾病联系起来.
杀死维生素D受体的小鼠证实了维生素在骨肌肉中的作用.
由于试验的局限性,人类的因果推断在伦理上具有挑战性.

研究的目的:

通过使用遗传方法,研究25...OH) D度与骨肌肉特征之间的因果关系.
为了探索与可能的缩症和缩性肥胖症的关联.
在试验中提供安全的因果洞察,而无需直接操纵维生素D.

主要方法:

使用英国生物库数据 (多达307,281名参与者) 进行了门德尔随机化 (MR) 分析.
35个基因变异被用于仪器25(OH) D水平.
分析包括握力的强度,骨肌肉质量,可能的皮症和皮性肥胖症.

主要成果:

基因预测较高的25(OH) D与更大的握力 (每10单位增加0.11公斤) 和适度的骨肌肉质量增加 (0.01公斤) 相关.
暗示性证据表明,较高25(OH) D (OR 0.96) 的可能性较低,较高的25(OH) D (OR 0.96) 的可能性较低.
这种关联在非肥胖的可能的肉病例中观察到,但在肉肥胖症中没有观察到.

结论:

这项研究支持25~OH) D与骨肌肉健康之间存在因果关系.
维生素D的充足可能有助于减少与年龄相关的肌肉衰弱.
预防维生素D缺乏症可能是维持肌肉功能的一种策略.

关键词:

抓地力抓地力抓地力抓地力营养状态营养状况公共卫生公共卫生.这种类型的麻症是sarcopenia.萨尔科佩尼克肥胖症肥胖症这是骨肌肉的骨架肌肉.维生素D是维生素D的重要组成部分.维生素D缺乏症维生素D缺乏症

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