天然化合物在饮食相关的肝炎中具有抗血管效应
Sara Novi1, Vincenzo Vestuto1, Pietro Campiglia1
1Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy.
Nutrients
|June 28, 2023
概括
针对血管生成的天然化合物显示出治疗酒精和非酒精性脂肪肝炎的前景. 对这些抗血管性疗法的进一步研究可能为肝炎和疾病进展提供新的治疗方法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 酒精性肝病 (ALD) 和非酒精性脂肪性肝病 (NAFLD) 是全球慢性肝病的主要原因.
- 无论是ALD还是NAFLD,都可以发展成严重的形式,如酒精性脂肪肝炎 (ASH) 和非酒精性脂肪肝炎 (NASH),其特点是炎症,纤维化和病态血管生成.
- 这种进展会造成肝损伤,缺氧和进一步损伤的循环,可能导致代谢综合征和肝细胞癌等并发症.
研究的目的:
- 审查天然抗血管生成化合物的分子机制.
- 评估它们在预防和控制肝脏疾病,特别是脂肪肝炎方面的潜在治疗益处.
- 了解这些化合物如何解决由不平衡饮食驱动的肝炎.
主要方法:
- 文献综述侧重于天然抗血管生成产品.
- 对它们对脂肪肝炎的影响背后的分子机制的分析.
- 在临床前和临床背景下评估治疗潜力 (隐含).
主要成果:
- 天然的抗血管性化合物显示出对抗与脂肪肝炎相关的肝炎和纤维化有潜力.
- 了解它们的机制可以指导肝脏疾病的新型治疗策略的开发.
- 这些化合物可能在与饮食失衡相关的肝脏疾病中发挥预防或控制作用.
结论:
- 抗血管性疗法,特别是使用天然化合物,对管理ALD和NAFLD具有显著的前景.
- 向血管生成是打破肝损伤和脂肪肝炎进展循环的关键策略.
- 对这些天然药物的进一步研究是有效治疗肝病的必要条件.
相关概念视频
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Mechanism of Angiogenesis
5.6K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.6K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
706
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
706
Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15


