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评估和维生素A之间对肠道功能,形态和微生物群的相互作用 (Gallus gallus)

Cydney Jackson¹, Nikolai Kolba¹, Elad Tako¹

¹Department of Food Science, Cornell University, Ithaca, NY 14850, USA.

|June 28, 2023

概括

在肉蛋中补充 (Zn) 和维生素A (VA),改善了肠道健康,改变了肠道细菌. 这两种营养素的低剂量 (ZLRL) 对基因表达和肠道微生物组合有显著影响.

科学领域:

动物科学动物科学
营养生物化学营养生物化学
微生物学微生物学

背景情况:

(Zn) 和维生素A (VA) 的微量营养素缺乏是全球普遍存在的健康问题.
现有研究表明,Zn和VA之间在维持生理状态方面存在显著的相互作用.
了解这种相互作用对于改善动物健康和生产率至关重要.

研究的目的:

为了研究Zn和VA,单独或组合,对肉 (Gallus gallus) 的肠功能和形态的影响.
评估这些微量营养素对肠道微生物组组成的影响.
评估Zn和VA补充剂的剂量依赖作用.

主要方法:

肥沃的肉蛋通过羊水注射,用各种度的 Zn 和 VA (或对照物) 进行了处理.
建立了9个治疗组,包括对照组 (没有注射,水,油) 和不同水平的 Zn (正常/低) 和 VA (正常/低).
在化后收集了肠道组织和脏内容,以分析基因表达,形态和微生物群体.

主要成果:

低剂量和维生素A (ZLRL) 显著改变了与运输相关的基因表达 (减少ZIP4,调高ZNT1).
胚胎内注射Zn和VA通常改善了十二指肠形态 (增加表面积) 并减少了密室深度.
正常和低剂量联合治疗 (ZNRN,ZLRL) 减少了关键肠道细菌属 (Bifidobacterium,Clostridium) 的丰富性,而不是油控.

结论:

和维生素A的胚胎内给药可以增强肉肠表皮的发育和功能.
联合低剂量治疗 (ZLRL) 对肠道生物标志物和肠道微生物组调节均表现出显著的影响.
需要进一步的研究来探索这种补充方法所产生的长期影响和详细的微生物群概况.

关键词:

盖勒斯 (Gallus) 是一个叫做"盖勒斯 (Gallus) "的动物.刷边缘膜膜的刷边缘膜我们的肠道是肠道.微生物组是一个微生物组.视网类药物视网类药物维生素A是一种维生素A.,和的使用情况.

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