在哺乳期服用益生菌补充剂会影响产后生长受限制小鼠的微生物殖民
Lucie Marousez1, Léa Chantal Tran1,2, Edwina Micours1
1Univ. Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France.
Nutrients
|June 28, 2023
概括
早期的益生菌纤维 (PF) 补充可能会改善生长受限小鼠的肠道微生物群的建立. 这种干预影响了微生物的组成,可能会减轻与周围营养不良相关的长期健康问题.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 发展生物学 发展生物学
背景情况:
- 不足够的围产期营养会损害肠道屏障的成熟,导致慢性疾病.
- 肠道微生物群在肠道屏障发展中起着至关重要的作用.
- 早期的生活营养显著影响长期健康结果.
研究的目的:
- 研究早期产后益生菌纤维 (PF) 补充对产后生长受限 (PNGR) 小鼠生长,肠道形态和微生物群的影响.
- 了解PF如何影响PNGR小鼠的肠道微生物殖民和短链脂肪酸 (SCFA) 生产.
主要方法:
- 产后生长限制 (PNGR) 在小鼠中被诱导,通过创造大子.
- PNGR和对照 (CTRL) 幼从出生后的第8天到第20天每天口服益生菌纤维 (PF) 或水.
- 肠道形态,微生物组成和SCFA产量在断奶 (产后21日) 时被评估.
主要成果:
- PNGR小鼠在断奶时体重减小,乳腺密室深度降低.
- PNGR与肠道微生物群的改变有关,包括Lachnospiraceae和Oscillospiraceae的减少,以及Akkermansia和Enterococcus的增加.
- 在PNGR小鼠中补充PF丰富了Bacteroides和Parabacteroides属,同时减少了Proteobacteria;在对照小鼠中,PF增加了Akkermansia的存在.
结论:
- 产后生长限制会对乳腺密室成熟和奶时肠道微生物群的殖民产生负面影响.
- 益生菌纤维补充剂显示出在关键的出生后早期期间改善肠道微生物群的建立的潜力.
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