完全母乳养和过敏性疾病 - - 长期保护还是反弹效应?
Lars Libuda1,2, Birgit Filipiak-Pittroff2,3, Marie Standl4,5
1Institute of Nutrition, Consumption and Health, Faculty of Natural Sciences, Paderborn University, Warburger Straße 100, 33098 Paderborn, Germany.
幼儿期湿疹强烈预测到年轻成人中的过敏. 随着时间的推移,母乳养对湿疹的保护减弱,在这项长期研究中没有证实反弹效应.
科学领域:
- 儿科过敏和免疫学
- 纵向队列研究 纵向队列研究
- 流行病学 流行病学
背景情况:
- 以前的研究表明,母乳养可以预防早期湿疹.
- 这种保护在青春期可能会减弱,这引发了关于潜在的反弹效应的问题.
研究的目的:
- 评估早期湿疹对过敏发展的长期影响,直到年轻成人.
- 为了确定早期湿疹是否会影响母乳养与过敏之间的关联.
主要方法:
- 来自GINIplus研究的数据分析长达20年的时间 (N=4058).
- 医生诊断的亚托皮性湿疹,喘和鼻炎的评估.
- 使用一般化估计方程,对调整的赔率比率进行建模.
主要成果:
- 早期湿疹显著预测了湿疹,喘和鼻炎到年轻成人.
- 早期湿疹和湿疹之间的联系随着年龄的增长而减少.
- 从5岁到20岁,母乳养与过敏之间没有发现显著的关联.
- 早期湿疹通常不会改变母乳养与过敏的联系,除了特定子组的鼻炎.
结论:
- 早发性湿疹是过敏持续到年轻成年人的强烈预测因素.
- 哺乳对婴儿湿疹的保护作用不延伸到年轻成人,并且没有观察到反弹效应.
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