糖尿病慢性冠状动脉综合征患者的炎症和胰岛素抵抗
Tianyu Li1, Peizhi Wang1, Xiaozeng Wang2
1National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
在患有慢性冠状动脉综合征的糖尿病患者中,高胰岛素抵抗和全身炎症显著增加心血管事件风险. 系统性炎症部分解释了胰岛素抵抗与心脏不良事件之间的联系.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 关于胰岛素抵抗,全身炎症和慢性冠状动脉综合征 (CCS) 糖尿病患者心血管事件之间的相互作用的数据有限.
- 了解这些组合和调解效应对于风险分层和风险管理至关重要.
研究的目的:
- 研究胰岛素抵抗和全身炎症在预测糖尿病CCS患者主要心脏不良事件 (MACE) 中的联合和调解作用.
- 评估结合胰岛素抵抗和炎症标志物的有效性,以确定风险.
主要方法:
- 对4419名糖尿病CCS患者的多中心前队列的二次分析.
- 三甘-葡萄糖指数 (TyG) 用于胰岛素耐药性和高敏感性C反应蛋白 (hsCRP) 系统性炎症.
- 考克斯回归和调解分析以评估关联和hsCRP的调解作用.
主要成果:
- 在TyG和hsCRP水平升高的患者中观察到MACE的高风险 (HR=1.82,P=0.002).
- 在TyG和MACE之间的关联中,HSCRP显著调解了14.37% (P<0.001).
- 胰岛素抵抗和炎症对心血管风险的协同作用是显而易见的.
结论:
- 胰岛素抵抗和全身炎症协同提高糖尿病CCS患者心血管事件的风险.
- 系统性炎症部分介导了胰岛素抵抗和不良临床结果之间的联系.
- 对TyG和hsCRP的联合评估有助于识别高风险个体,表明对炎症控制有潜在的益处.
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