非对称脂质囊泡:作为创新的药物输送系统的技术,应用和未来前景
Denisse Gardea-Gutiérrez1, Eduardo Núñez-García1, Berenice E Oseguera-Guerra1
1Tecnologico de Monterrey, School of Engineering and Sciences, Av. H. Colegio Militar 4700, Nombre de Dios, Chihuahua 31300, Chih, Mexico.
Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
概括
不对称的脂质体,工程脂质囊泡,通过改善药物保护和生物相容性,提供增强的药物输送. 计算分析有助于设计这些先进的纳米载体用于透皮应用.
科学领域:
- 纳米技术和制药科学 纳米技术和制药科学
- 生物材料和药物输送系统
背景情况:
- 脂质体是被广泛研究的脂质纳米结构,用于药物输送,因为它们的生物相容性.
- 不对称的脂质体具有不同的内部和外部脂质层,使得定制的药物兼容性和稳定性.
研究的目的:
- 审查非对称脂质体的应用,优势和合成.
- 探索in silico分析在设计和理解不对称的脂质体机制中的作用.
主要方法:
- 对不对称脂质体应用和合成的文献综述.
- 讨论用于脂质体行为的形分析的计算工具.
主要成果:
- 不对称的脂质体提供了更好的药物保护和稳定性.
- 它们的双重工程设计增强了通过皮肤递送药物,而不会影响吸附或生物相容性.
结论:
- 不对称的脂质体代表了药物输送系统的有希望的进步.
- 在 silico 方法对于优化这些纳米载体的设计和应用是有价值的.
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