设计和优化Omeprazole-Curcumin-LoadedHydrogel珠子涂上奇托桑用于治疗胃潰瘍的设计和优化
Eman J Heikal1,2, Rashad M Kaoud3, Shadeed Gad1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
新的水凝珠结合了奥梅普拉 (OMP) 和黄素 (CURC) 显示了增强的抗效果. 这种持续释放的配方为胃潰瘍提供了一个有前途的新疗法.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 自然产品化学 自然产品化学
背景情况:
- 胃潰瘍需要有效的藥物治療.
- 奥梅普拉 (OMP) 和黄素 (CURC) 具有治疗潜力,但在交付方面面临挑战.
- 提高OMP和CURC的可溶性和持续释放对于提高疗效至关重要.
研究的目的:
- 为了制定和表征新型的含有欧梅普拉和黄素的水凝珠,用于治疗胃.
- 改善溶解并实现两种活性药物成分的持续释放.
- 为了评估与单个成分相比,开发的配方的抗性疗效.
主要方法:
- 奥梅普拉和黄素与氧-β-环氧氨酸复合,以提高溶解度.
- 组合复合物被装入酸盐珠中,并涂上基托以持续释放.
- 描述包括珠子大小,胀,捕获效率,以及体外药物释放研究.
- 通过将优化的配方 (F8) 与免费的OMP和仅含OMP的珠子进行比较,评估了抗原影响.
主要成果:
- 优化的配方 (F8) 表现出高的捕获效率 (87.44 ± 1.88%) 和胀 (800.00 ± 6.2%).
- 实现了持续释放,与自由复合体相比,从珠子中释放的OMP和CURC明显较慢.
- 在6周内,OMP/CURC水凝珠显示出优越的稳定性.
- 结合的珠子显示出比单独的OMP或CURC配方更强大的抗原作用.
结论:
- 开发的欧梅普拉/库尔库明水凝珠提供了一个有前途的持续释放药物递送系统.
- 与传统治疗相比,这种配方显著提高了抗的有效性.
- 这项研究强调了这些双重药物载荷珠在治疗胃的潜在应用.
更多相关视频
08:39Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
05:08Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
相关概念视频
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
