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德克索鲁比配方的最新进展提高了药理动力学和瘤向性的作用

Jihoon Lee¹, Min-Koo Choi², Im-Sook Song¹

¹BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)

|June 28, 2023

概括

多克索鲁比 (DOX) 化疗面临药物耐药性和毒性方面的挑战. 新的口服配方旨在通过增强肠道吸收和减少副作用来改善DOX的输送和疗效.

科学领域:

药理学药理学是指药理学的学科.
在瘤学瘤学.
药物运输药物运输药物运输

背景情况:

多克索鲁比 (DOX) 是固体瘤的重要化疗剂,通过活性氧物种和DNA相互作用诱导亡.
然而,DOX的有效性受到获得的耐药性和心脏毒性,以及由于肠道透性低和P-糖蛋白排泄而导致的口服生物可用性差的限制.
目前的亲肠道配方,如脂质体和纳米颗粒,旨在提高治疗指数,但口服仍然是一个重大挑战.

研究的目的:

审查多克索鲁比 (DOX) 配方的进展,重点关注克服耐药性和毒性的策略.
探索口服生物可用DOX配方的开发,以改善癌症治疗.
确定关键技术,促进从静脉注射到口服DOX输送的过渡.

主要方法:

对门用多克索鲁比 (DOX) 配方 (脂质体,体,纳米颗粒,合物) 的现有文献的综述.
分析提高口服生物可用性的策略,包括pH/redox敏感系统,受体向,粘粘性和紧接节调节.
对P-glycoprotein (P-gp) 抑制和增强肠道透性的临床前方法的评估.

主要成果:

亲肠道的DOX配方在临床试验中显示出有前途的改善疗效.
目前正在开发pH/redox敏感和有针对性的系统,以克服DOX耐药性并降低毒性.
临床前研究表明,用于口服DOX输送的粘膜粘合和透增强策略的潜力.

结论:

开发口服生物可利用的多克索鲁比 (DOX) 配方是改善癌症治疗的关键趋势.
粘粘技术,透增强和P-gp抑制对于成功的口服DOX输送至关重要.
功能辅助剂和药物动力学调制可能会推动口服DOX配方的未来发展.

关键词:

德克索鲁比 (DOX) 是一种药物耐药性耐药性药物耐药性策略的制定策略的制定.口服配方是一种口服配方.

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