二元聚合物表面活性剂混合物用于开发新型洛特普雷多尔埃他酸纳米细胞眼滴
Silvia Tampucci1,2, Daniela Monti1,2, Susi Burgalassi1,2
1Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
概括
这项研究开发了使用聚合物表面活性剂的稳定纳米溶液,用于 loteprednol etabonate (LE). 这些配方增强了药物的溶解性,并显示持续释放,表明眼睛炎症疾病治疗的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 局部皮质类固醇用于眼部炎症.
- 开发有效的眼科配方药物,如 loteprednol etabonate (LE) 是至关重要的.
- 高药物负载和稳定性是眼科药物输送的关键挑战.
研究的目的:
- 为了评估两性聚合物表面活性剂的二元混合物的溶解效果.
- 为了创建稳定的nanomicellar解决方案与高 loteprednol和乙烯酸盐 (LE) 的负载.
- 描述开发的纳米细胞配方的物理和化学特性.
主要方法:
- 使用 loteprednol etabonate (LE) 和TPGS/HS聚合物表面活性剂制备和表征纳米溶液.
- 对纳米细胞大小,多分散性指数,透明度和可过性的分析.
- 确定临界细胞度 (CMC) 和相互作用参数.
- 不同扫描热量计 (DSC) 确认药物表面活性剂相互作用.
- 在角膜上皮细胞上的体外药物释放研究和细胞毒性测定.
主要成果:
- 开发的LE-TPGS/HS纳米细胞具有高药载荷 (0.253 mg/mL),小尺寸 (13.57 nm) 和均分布 (PDI=0.271).
- 配方是透明的,可过的,在4°C下稳定30天.
- 通过CMC,相互作用参数和DSC分析确认了药物表面活性剂相互作用.
- 在体外持续释放LE44小时 (>40%封装药物).
- 在角膜上皮细胞上没有显著的细胞毒性作用.
结论:
- 两种TPGS/HS的二元混合物有效地将洛特前乙酸盐 (LE) 溶解为稳定的纳米细胞溶液.
- 开发的纳米细胞表现出有利的物理化学特性和持续的药物释放.
- 该配方对治疗眼部炎症状况有望,毒性降低.
关键词:
D-alpha-tocopheryl聚乙烯甘醇 1000 顺酸盐的使用情况科利福® HS-15 系列这是一个TPGS系统.关键的微粒度是微粒度的关键.洛特普雷德诺尔和乙酸盐的使用情况混合的纳米微粒.眼部药物输送是指眼部药物输送.更多相关视频
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