在老年人中使用潜在不适当药物的性别差异
Monira Alwhaibi1,2, Bander Balkhi1,3
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11149, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
概括
在沙特阿拉伯,老年女性使用潜在不合适的药物 (PIM) 比男性更为常见. 这凸显了老年人处方实践和相关健康状况的性别差异.
科学领域:
- 老年人药理学 老年人药理学
- 药物安全 药物安全
- 健康差异 在健康上的差异
背景情况:
- 潜在不适当的药物 (PIM) 使用是老年人的一个重大问题,导致不良的健康结果.
- 老年女性通常使用的药物比男性更多,PIM的处方模式可能因性别而异.
- 了解PIM使用的基于性别的差异对于改善老年人群中药物安全至关重要.
研究的目的:
- 检查沙特阿拉伯老年人处方潜在不合适药物的性别差异.
- 确定特定的PIM类别和相关的临床因素,这些因素在老年男性和女性之间存在差异.
- 在老年人群中为更安全的药物治疗实践提供有针对性的干预信息.
主要方法:
- 沙特阿拉伯一家医院电子病历的回顾性分析.
- 包括65岁及以上的门诊患者.
- 基于Beers标准的PIM利用率评估,使用描述性统计和物流回归分析.
主要成果:
- 该研究包括4062名老年人 (56.8%是女性),其中58.3%的女性和44.7%的男性使用PIM.
- 女性使用心血管和胃肠道PIM的比例更高,而男性使用PIM与高血压和缺血性心脏病有关.
- 与女性使用PIM相关的因素包括年龄,脂质不良,慢性病和骨质疏松症.
结论:
- 在沙特阿拉伯的老年人中,PIM处方模式存在显著的性别差异,女性患病率更高.
- 与PIM使用相关的临床和社会经济特征在性别之间存在差异.
- 研究结果强调需要针对性别的干预措施,以优化药物处方和提高老年人药物安全.
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