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Updated: Jul 25, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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发现了一种具有抗菌作用的新基-三甲基胺混合体:设计,合成和结构-活动关系研究研究

Joana Moreira1,2, Patrícia M A Silva3,4, Matilde Barros5

  • 1Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
PubMed
概括

一种新型的甲-trimethoxycinnamide混合体 (7) 和其类似物被合成并测试了抗癌活性. 化合物7通过诱导独立于p53通路的线性停止来选择性抑制结直肠瘤细胞生长.

关键词:
它具有抗瘤活性.灭症 (apoptosis) 是一种死亡的过程.石灰石是指石灰石块的组成部分.这种药物是二甲基胺.混合物 混合物 混合物发生线粒分裂 (mitosis).在 p53 里,p53 是一个 p53 的类型.

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