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立方体使用与食道癌的关系
Sarang Jang1, Hyo Geun Choi2,3, Mi Jung Kwon4
1Department of Public Health, Sahmyook University, Seoul 01795, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|June 28, 2023
概括
在韩国人群中,长期使用他类药物与食道癌的风险或死亡率降低无关. 进一步的小组分析显示,在各种人口和临床因素中没有显著的保护作用.
科学领域:
- 在瘤学瘤学.
- 心血管药理学心血管药理学
- 流行病学 流行病学
背景情况:
- 类药物被广泛用于预防心血管疾病.
- 目前正在调查他类药物对癌症风险的潜在类效应.
- 关于他类药物使用和食道癌症之间的关联存在有限的数据.
研究的目的:
- 评估长期使用他类药物和食道癌症诊断之间的关联.
- 评估他类药物持续时间对食道癌死亡率的影响.
- 在韩国人口群体中探索这些关联.
主要方法:
- 使用韩国国家医疗保险服务-健康查数据 (2002-2019) 的回顾性队列研究.
- 匹配食道癌症患者与对照参与者.
- 倾向性得分重叠权重和多变量逻辑回归分析了他类药物处方持续时间 (<180,180-545,>545天) 和死亡率.
主要成果:
- 长期使用他类药物 (>180天) 与食道癌诊断的几率更高有关 (OR=1.30-1.29).
- 在他类药物持续时间和食道癌死亡率之间没有发现显著的关联.
- 某些子组 (例如,非吸烟者,低SBP/DBP) 显示他类药物处方的几率较低,但总体而言,他类药物没有降低食道癌风险或死亡率.
结论:
- 长期的他类药物处方时间与韩国成年人群的食道癌诊断或死亡率降低无关.
- 水友性和脂友性他类药物都没有显示出对食道癌的保护作用.
- 研究结果表明,他类药物在预防食道癌或改善这一群体的存活率方面没有作用.
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