使用多变量分析来揭示两种香品种及其抗癌和抗氧化活性之间的差异
Dana Atoum1,2, Ignacio Fernandez-Pastor1,3, Louise Young1
1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Plants (Basel, Switzerland)
|June 28, 2023
概括
环境条件显著影响德国香 (Matricaria chamomilla) 中的二次代谢产物. 欧洲香提取物显示出抗癌和抗氧化特性,而约旦提取物仅表现出抗氧化活性.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 植物科学 植物科学
背景情况:
- 星座植物家族,包括香 (Matricaria chamomilla),富含生物活性黄和.
- 不同的环境条件可以导致植物品种之间的二次代谢物概况的显著变化.
- 多变量统计分析是评估这些变量的关键工具.
研究的目的:
- 研究不同的环境条件对约旦和欧洲香品种的代谢特征的影响.
- 评估这两种香品种提取物的生物活性,特别是抗癌和抗氧化特性.
主要方法:
- 使用不同极性的溶剂制备原始提取物.
- 对半极分数进行了生物活性测定.
- 在选定的提取物上进行了进一步的分离和活性测定.
- 结构阐明使用HPLC-MS,脱复制和2DNMR技术.
主要成果:
- 欧洲香的半极分量显示出抗癌和抗氧化活性.
- 约旦香的半极分量表现出抗氧化活性.
- 在两种品种中都发现了具有抗氧化能力的二咖啡基酸异构体.
- 欧洲香产生的*Z*-葡萄糖酸 (抗氧化剂) 和化合物chrysosplenetin和apigenin (抗癌).
结论:
- 环境因素显著影响从约旦和欧洲香中分离出来的化合物的类型.
- 不同的化学特征与生物活动中观察到的差异相关.
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