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准备用于肺部应用的同形乐沃素系统

Aljoscha Gabelmann1,2, Claus-Michael Lehr2,3, Holger Grohganz1

  • 1Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Pharmaceutics
|June 28, 2023
PubMed
概括

开发新的抗生素配方对于打击抗菌素耐药性至关重要. 这项研究使用同形的LEV-L-氨酸 (ARG) 颗粒制造了肺部的Levfloxacin (LEV) 配方,改善了药物输送并减少了副作用.

关键词:
气溶是一种气溶.同形态的同形态.干粉吸入吸入方法干粉吸入方法颗粒大小 颗粒大小过程中的过程过程过程.喷雾干燥 喷雾干燥可持续性 可持续性 可持续性

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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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