审查粉末凝聚力对连续直接压缩 (CDC) 性能的影响
Owen Jones-Salkey1,2, Zoe Chu1,2, Andrew Ingram2
1Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK.
Pharmaceutics
|June 28, 2023
概括
制药中的持续直接压缩 (CDC) 面临粉末凝聚力的挑战,影响流量. 本综述研究了凝聚力控制方法如何影响CDC单位的操作,如食,混合和片剂,以更好地管理粉末.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 化学工程是化学工程的组成部分.
- 材料科学是一种材料科学.
背景情况:
- 制药行业正在从批量制造转向连续制造工艺.
- 连续直接压缩 (CDC) 是一种基于粉末的简化连续工艺,单位操作较少.
- 有效的粉末流动性和可分片性对于成功的CDC操作至关重要.
研究的目的:
- 在CDC中审查和整合有关粉末凝聚力的文献.
- 分析凝聚力控制策略对疾病预防控制中心单位操作 (养,混合,片剂) 的影响.
- 确定知识缺口和未来的研究方向,以管理CDC中的凝聚性粉末.
主要方法:
- 关于粉末凝聚力和CDC的系统文献综述.
- 对研究凝聚力控制方法的研究进行分析.
- 对粉末料,混合和压缩的影响的评估.
主要成果:
- 粉末凝聚力显著阻碍了粉末流动,这是CDC的一个主要障碍.
- 凝聚力控制策略可能会对下游单位运营产生负面影响.
- 关于凝聚力控制措施下游影响的研究有限.
结论:
- 管理粉末凝聚力对于有效的CDC至关重要.
- 需要进一步的研究来理解和减轻凝聚力控制策略的下游影响.
- 优化凝聚力控制对于在制药制造业中成功实施CDC至关重要.
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