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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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基于基托桑的优化纳米乳液改善了素的释放.

Camila Diedrich1, Isabella C Zittlau1, Najeh M Khalil1

  • 1Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Guarapuava 85040-167, Brazil.

Pharmaceutics
|June 28, 2023
PubMed
概括
此摘要是机器生成的。

基索基纳米乳液有效封装醇 (LUT),增强其溶解性,并使其可用于潜在治疗应用的可控释放.

关键词:
基多酸盐的使用方法药物释放药物释放药物释放药物释放药物优化的优化优化优化.响应表面方法的方法.稳定的稳定性 稳定的稳定性

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科学领域:

  • 纳米技术 纳米技术
  • 材料科学 材料科学 材料科学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 素 (LUT) 是一种具有抗氧化,抗炎,神经保护和抗瘤特性的黄类化合物,由于水溶性有限,其口服吸收不良.
  • 纳米封装提供了一种有前途的策略,可以提高像LUT这样的难溶化合物的可溶性和生物可用性.

研究的目的:

  • 开发和优化基于酸盐的纳米乳液 (NECh-LUT) 用于黄素 (LUT) 的封装.
  • 描述开发的纳米乳液的物理化学特性和稳定性.
  • 评估从纳米乳液系统中LUT的体外释放特征.

主要方法:

  • 使用2^3因数设计,以优化油,水和表面活性剂度的基索基纳米乳液 (NECh-LUT) 的配方.
  • 使用动态光散射 (DLS) 对尺寸和多分散度指数 (PDI),泽塔电位测量和传输电子显微镜 (TEM) 的纳米乳液的表征.
  • 评估封装效率,质行为,小角度X射线散射 (SAXS),室温稳定性研究和体外药物释放试验.

主要成果:

  • 优化的NECh-LUT的平均粒子直径为67.5nm,PDI为0.174和zeta电位为+12.8mV,封装效率为85.49%.
  • TEM证实了球形形态,风学分析表明了牛顿行为,SAXS揭示了双模特征.
  • 在室温下,NECh-LUT在30天内表现出良好的稳定性,持续释放LUT长达72小时.

结论:

  • 基托基纳米乳液提供了一个有效的系统,用于封装黄素,显著提高其溶解性,并使控制释放.
  • 优化的NECh-LUT配方表现出有利的物理化学特性,稳定性和药物释放动力学.
  • NECh-LUT具有显著的潜力,作为一种新的治疗选择,用于需要输送黄素的各种疾病.