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含有莫林的固体脂质纳米颗粒:制备,表征和活体透研究

Federica De Gaetano¹, Consuelo Celesti², Giuseppe Paladini³

¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

|June 28, 2023

概括

固体脂质纳米粒子 (SLNs) 有效地封装了莫林 (MRN),增强了其传递. 这些SLN改进了MRN.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

生物活性化合物具有较低的毒性,但具有较差的溶解性和生物可用性.
固体脂质纳米颗粒 (SLN) 正在成为先进的药物输送系统,以克服这些局限性.

研究的目的:

准备和表征使用康普瑞托尔® 888 ATO (COM) 或索利® 80H (PHO) 的摩林 (MRN) 载荷SLN (MRN-SLN).
评估MRN-SLN的物理化学,形态和技术特性,以改善药物输送.

主要方法:

通过使用COM或PHO脂质的溶剂乳化/扩散来制备MRN-SLNs.
描述包括物理化学,形态学,封装效率,体外释放和体外透研究.
光谱和热分析证实了MRN与脂质的相互作用.

主要成果:

获得了带负泽塔电位的球形,非聚合的MRN-SLN (60-70nm).
实现了高封装效率 (~99%),特别是在10%的理论MRN负载下.
实验室研究显示,在24小时内释放了约60%的MRN,持续释放超过10天.
活体研究表明,SLN是MRN通过牛鼻腔粘膜的透增强剂.

结论:

用COM或PHO制备的MRN-SLN具有药物输送的有利特征.
开发的SLN增强了莫林的封装和释放特征.
SLN显示出作为有效的透增强剂的潜力,用于鼻腔药物输送.

关键词:

通过ex vivo透进行了透.在体外释放的 in vitro 释放.莫里恩·莫林 (Morin Morin) 是一个著名的作家.物理和化学表征.固体脂质纳米粒子固体脂质纳米粒子

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