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通过Janus和Dendrimer颗粒来实现药品的特定目标交付和生物可用性

Jaison Jeevanandam¹, Kei Xian Tan², João Rodrigues¹

¹CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.

|June 28, 2023

概括

纳米尺寸的Janus和树枝状分子提供有针对性的药物输送和提高生物可用性. 混合纳米粒子将两者结合起来,有望克服局限性并推进制药应用.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
制药科学制药科学

背景情况:

纳米尺寸的Janus和树突分子是用于药物输送的先进纳米载体.
简斯粒子为多种药物输送和组织特定向提供了独特的平台.
登德里默提供可调整的表面功能,以增强药物向和释放.

研究的目的:

讨论纳米尺寸的Janus和树突分子在特定目标药物输送中的应用.
探索它们在提高药品生物可用性方面的作用.
为了检查Janus-dendrimer混合纳米粒子的发展.

主要方法:

关于用于药物输送的Janus和树突分子纳米粒子现有文献的综述.
分析粒子特性,包括大小,形状和表面功能.
讨论混合系统的开发及其优势.

主要成果:

雅努斯粒子和树突粒子都提高了药物的溶解性,稳定性,细胞吸收,并降低了毒性.
表面功能可以针对特定的目标进行定制,例如,癌细胞.
混合纳米粒子利用结合的特性来克服个人的局限性.

结论:

纳米尺寸的Janus和树枝状粒体对药物输送和生物可用性显示出显著的希望.
优化纳米载体设计对于临床转化至关重要.
亚努斯-登德里默混合纳米粒子代表了先进药物输送系统的有希望的战略.

关键词:

亚努斯纳米颗粒的使用生物相容性生物相容性树枝状的树枝体.药物输送是药物输送的过程.纳米制剂的纳米配方药品制品制品制品制品制品制品制品制品

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