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对网状气溶性等离子体的生物制药评估,迈向ARDS治疗的一步

Lucia Vizzoni^1,2, Chiara Migone¹, Brunella Grassiri¹

¹Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

|June 28, 2023

概括

塑原 (PLG) 网状雾化通过维持PLG,有效治疗急性呼吸困扰综合征 (ARDS).

科学领域:

肺部医学肺部医学
生物化学生化学
药理学药理学是指药理学的学科.

背景情况:

急性呼吸窘迫综合征 (ARDS) 是一种严重的肺损伤,死亡率高,管理复杂.
目前的ARDS治疗缺乏有效的选择,需要新的治疗策略.
ARDS涉及呼吸衰竭,纤维素沉积和高凝血,表明需要治疗炎症和凝血的药物.

研究的目的:

评估网状雾化在 ARDS 治疗基于等离子素的孤儿药物 (PLG-OMP) 的疗效.
评估雾化PLG的酶和免疫调节活性.
研究吸入PLG-OMP用于ARDS治疗的生物制药可行性.

主要方法:

使用振动网雾化器 (Aerogen® SoloTM) 进行PLG-OMP雾化.
试验室评估包括气溶沉积,蛋白质完整性,酶活性,粘液透和上皮浸透.
通过使用LPS激活的RAW 264.7巨细胞来评估免疫调节效应.

主要成果:

网状雾化产生了最佳的体外沉积 (90%在较低的冲击者部分).
雾化PLG保持了单体形式,糖形成分和94%的酶活性.
通过逆转LPS诱导的巨细胞激活,PLG表现出免疫调节活性.

结论:

网状雾化是用于ARDS的PLG-OMP的可行方法.
吸入PLG具有良好的粘液扩散和有限的全身吸收,具有良好的安全性.
雾化PLG具有对ARDS的治疗潜力,因为它具有抗炎和纤维解质的特性.

关键词:

在 ARDS 中,ARDS 是指 ARDS 的类型.这就是C-ARDS.在 COVID-19 疫情中,这就是SARS-CoV-2病毒.它具有免疫调节活性.肺在体外模型中的肺在体外模型塑原体是一种塑原体.肺部输送是通过肺部进行的.

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