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针对性微泡用于药物,基因和细胞在治疗和免疫治疗中的输送

J Angel Navarro-Becerra¹, Mark A Borden^1,2

¹Mechanical Engineering Department, University of Colorado Boulder, Boulder, CO 80309, USA.

|June 28, 2023

概括

向微气泡 (tMB) 是先进的超声响应载体,用于局部药物和基因传递. 本综述详细介绍了当前的tMB配方及其治疗应用,旨在提高治疗疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

微气泡 (MBs) 是含有脂外的气体填充颗粒 (1-10微米).
MBs可以用于药物,基因和细胞的向输送.
向的微气泡 (tMBs) 利用超声波来提高治疗效果.

研究的目的:

审查目前针对性微气泡 (tMB) 配方的最新情况.
要总结tMBs的超声波向传递应用.
探索改善tMB在诊断和治疗方面的表现的战略.

主要方法:

对增加药物负载的不同载体系统的概述.
分析各种准策略,以加强本地交付.
对tMB在药物,基因和细胞输送中的应用进行审查.

主要成果:

作为局部治疗的超声响应载体,tMBs显示出希望.
功能化策略可以提高药物负载和向效率.
通过有针对性的输送,tMBs可以增强治疗效果并最大限度地减少副作用.

结论:

目前的tMB配方提供了超声波向输送的先进功能.
对载体系统和准策略的进一步研究可以优化tMB的性能.
未来的方向旨在改善tMB,以提高诊断和治疗结果.

关键词:

免疫疗法免疫疗法有针对性的微气泡.治疗疗法治疗疗法治疗疗法超声波成像探测器的探测器用超声波准的输送.

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