一种新的控制方法Enterococcus faecalis通过同时治疗与蛋白质胺和氧化
1Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Pharmaceutics
|June 28, 2023
概括
将原胺与氧化结合起来可以有效地杀死Enterococcus faecalis,这是一个经常在根运河治疗后发现的有弹性的细菌. 这种新的方法显示了改善牙周炎控制的潜力.
科学领域:
- 微生物学 微生物学
- 牙周内科医院 牙周内科医院 牙周内科医院
- 生物材料是一种生物材料.
背景情况:
- 菌 (Enterococcus faecalis) 是一种有弹性的阳性细菌.
- 性耐受性高的E. faecalis有助于耐火性顶端牙周炎.
- E. faecalis可以在性环境中生存和繁殖,高达pH10的性环境.
研究的目的:
- 为了评估与氧化结合胺和胺对E. faecalis. 的疗效.
- 为了研究单独和与氧化结合的protamine的抗菌活性.
- 探索组合抗微生物剂的作用机制.
主要方法:
- 研究了protamine对E. faecalis. 的抗菌活性.
- 评估了E. faecalis在性条件下对氧化的耐受性.
- 评估了原胺和氧化联合治疗对E. faecalis活力的影响.
- 检查了细胞膜损伤和质氨酸内部化.
主要成果:
- 单独使用益生素可以降低E. faecalis的生长速度,但并不能杀菌.
- 在pH值为10的环境中,E. faecalis可以生存.
- 通过胺素 (250微克/毫升) 和氧化的联合治疗,可以完全杀死E. faecalis.
- 同时治疗增强了膜损伤和质氨酸内部化.
结论:
- 与原胺和氧化联合治疗在杀菌E. faecalis.方面非常有效.
- 协同抗菌活性可能涉及对细胞膜的联合作用.
- 这种组合提供了一种潜在的新型控制方法E. faecalis在根管治疗.
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