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功能化L-氨酸介质混合纳米颗粒用于pH响应的库尔库明的输送

Madhappan Santhamoorthy¹, Vanaraj Ramkumar¹, Kokila Thirupathi²

¹School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.

|June 28, 2023

概括

研究人员为向癌症治疗开发了L-氨酸修饰的半孔性二氧化纳米粒子 (MS@Lys NP). 这些纳米颗粒有效地以pH响应的方式输送黄素,一种抗癌剂,显示出药物输送应用的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

响应刺激的可控药物输送系统对于有效的药物载体至关重要.
半孔纳米颗粒为药物输送提供了一个多功能平台.
L-lysine功能化可以增强特定应用的纳米粒子特性.

研究的目的:

为了合成L-氨酸修饰的半孔性二氧化纳米粒子 (MS@Lys NPs).
用MS@Lys NPs.来研究黄素 (Cur) 的pH响应性药物输送.
为了评估MS@Lys NPs的体外细胞兼容性和细胞吸收.

主要方法:

使用3-glycidoxypropyl trimethoxy silane (GPTS) 合成半孔混合纳米颗粒 (MS@GPTS NP).
通过环开反应与L-氨酸的MS@GPTSNP的功能化.
使用仪器技术进行MS@Lys NP的表征.
在pH值7.4,6.5和4.0下评估黄素的药物负荷和pH响应药物释放.
使用MDA-MB-231细胞对体内细胞相容性和细胞吸收的评估.

主要成果:

成功合成和表征L-氨酸修饰的半孔性二氧化纳米粒子 (MS@Lys NPs).
证明了黄素的pH响应性药物递送,在较低的pH值下释放的强化.
MS@Lys NPs在MDA-MB-231癌细胞中表现出良好的体外细胞相容性和高效的细胞吸收.

结论:

MS@Lys NPs是有效的载体,可以传递黄素等抗癌剂的pH响应.
开发的纳米粒子显示了针对癌症治疗的潜在应用.
进一步的研究是有必要的,以探索MS@LysNP在体内治疗的疗效.

关键词:

在L-lysine的使用中.药物输送是药物输送的过程.半孔的二氧化纳米粒子.在pH刺激的过程中,表面的修改表面的修改

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