组合疗法作为对抗口腔癌的有希望的方法
João P N Silva1, Bárbara Pinto1, Luís Monteiro1
1UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.
Pharmaceutics
|June 28, 2023
概括
组合疗法通过向微管和信号通路来改善口腔癌的结果. 本综述分析了当前的策略,强调了它们在克服耐药性和增强治疗反应方面的有效性.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔癌是侵略性的,导致转移和高死亡率.
- 传统的治疗方法 (手术,化疗,辐射) 有显著的副作用.
- 组合疗法是局部晚期口腔癌的标准,改善了结果.
研究的目的:
- 为提供口腔癌综合疗法进展的深入分析.
- 探索当前的治疗选择和单一治疗的局限性.
- 要突出针对关键分子通路的组合方法.
主要方法:
- 对组合疗法的临床前和临床证据的审查.
- 对包括微管抑制剂和信号通路调节器在内的向药物的分析.
- 讨论组合策略的理由,有效性和挑战.
主要成果:
- 组合疗法显示治疗反应增强,克服药物耐药性.
- 准微管,DNA修复,EGFR,CDK,表观遗传阅读器和免疫检查点显示出有希望.
- 证据支持各种组合方法在临床前和临床环境中的有效性.
结论:
- 组合疗法对于改善口腔癌治疗结果至关重要.
- 解决毒性和个性化等挑战是临床翻译的关键.
- 未来的研究应该专注于优化口腔癌管理的组合策略.
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