在纳米配方中近期的进步为奎尔素的输送提供了补充
Ekaterina-Michaela Tomou1, Paraskevi Papakyriakopoulou2, Elmina-Marina Saitani2
1Section of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Pharmaceutics
|June 28, 2023
概括
奎尔素 (QUE) 的生物利用性因溶解性差而受到限制. 先进的纳米配方,包括基于脂质和聚合物的系统,显示出增强QUE输送和治疗疗效的前景.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 奎尔 (QUE) 是一种强效的黄醇,具有显著的药理特性.
- 低水溶性和 QUE 的广泛的第一通代谢阻碍了其口服和治疗效果.
研究的目的:
- 审查各种纳米配方的潜力,以改善奎尔西的生物可用性.
- 探索先进的药物输送纳米系统,以有效封装,向和控制Que的释放.
主要方法:
- 主要纳米系统类别,配方过程和表征技术的概述.
- 专注于基于脂质的纳米载体 (脂质体,NLC,SLN) 和基于聚合物的纳米载体 (菌体,水凝).
- 讨论替代配方,如循环德克斯特林,尼索姆和纳米乳液,用于各种管理途径.
主要成果:
- 基于脂质的纳米载体增强了QUE的口服吸收,向,抗氧化活性,并提供持续释放.
- 基于聚合物的纳米载体改善了Que的吸收,分布,新陈代谢,分泌和毒理学 (ADME) 概况.
- 各种纳米系统为克服QUE的配方挑战提供了有希望的策略.
结论:
- 先进的药物输送纳米系统对于开发有效的奎尔胺剂型至关重要.
- 纳米配方显著提高了QUE的生物可用性,疗效和药物动力学特征.
- 本综述强调了纳米技术在优化治疗应用中的Quercetin输送中的作用.
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