在患有类风湿性关节炎的患者中,甲状腺素反应的药物遗传性性别特异性影响
Francisco C Ceballos1, Eugenio Chamizo-Carmona2, Carmen Mata-Martín3,4
1Health Institute Carlos III (ISCIII), 15706 Santiago de Compostela, Spain.
Pharmaceutics
|June 28, 2023
概括
特定基因的遗传变异,如ITPA和ABCB1,可能会影响类风湿性关节炎中甲状腺素的反应. 临床因素对于预测RA患者治疗结果至关重要.
科学领域:
- 药物遗传学 药物遗传学
- 类风湿性关节炎的治疗方法
- 药物的有效性和毒性.
背景情况:
- 甲托雷克萨特 (MTX) 是类风湿性关节炎 (RA) 的标准治疗方法,但患者的反应有很大差异.
- 药物遗传学通过识别预测性遗传标志物,为个性化MTX治疗提供了潜在的潜力.
- 目前对RA中MTX药物遗传学的研究缺乏一致的发现.
研究的目的:
- 在一个大 RA 患者队列中识别与 MTX 疗效和毒性相关的遗传标记.
- 探索临床共变量和性别对MTX反应的影响.
- 推进风湿性关节炎治疗的个性化医疗方法.
主要方法:
- 对包括ITPA,ABCB1,FPGS,GH,MTHFR和ADA在内的基因中的遗传多态度的分析.
- 关联研究将遗传变异与MTX反应,疾病缓解和不良事件联系起来.
- 在预测建模中研究临床共变量和性别特异效应.
主要成果:
- 确定了ITPA rs1127354和ABCB1 rs1045642与MTX响应之间的关联.
- 与FPGS rs1544105,GGH rs1800909和MTHFR多态性与疾病缓解有关.
- 发现GGH rs1800909和MTHFR rs1801131与不良事件相关;ADA rs244076和MTHFR变体也涉及.
- 临床共变量在预测模型中比遗传标记更为重要.
结论:
- 药物遗传标记显示出在RA中个性化MTX治疗的潜力.
- 临床因素在预测MTX结果方面发挥着比已识别的遗传变异更重要的作用.
- 需要进一步的研究来阐明MTX反应和RA中毒性的复杂机制.
更多相关视频
04:50Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
266
07:44Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
Published on: July 14, 2023
1.2K
相关概念视频
01:19Factors Affecting Drug Biotransformation: Biological
185
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
185
01:21Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
01:17Phase II Reactions: Methylation Reactions
240
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
240
01:11Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
201
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
201
01:27Combined Effects of Drugs: Synergism
4.1K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.1K